The game was unprofitable for Ubisoft, prompting it to turn another Wii U exclusive, Rayman Legends, into a multiplatform game. Technical problems, such as glitches and load times, were criticized. Critics had mixed opinions about gameplay, multiplayer, story and use of the GamePad. It received generally positive reviews from critics, with the game's emphasis on survival horror, atmosphere, and the permadeath system praised. Ubisoft Bucharest led development of the game's multiplayer portion.

London was chosen as the game's setting because of its blend of modern and medieval architecture and its rich history.

Among other video games, ZombiU was influenced by Resident Evil, Condemned: Criminal Origins and Peter Jackson's King Kong. Many of the game's features, including the GamePad feature and the permadeath feature, went through several iterations. Originally envisioned as a spin-off of the Raving Rabbids franchise and a fast-paced first-person shooter, Killer Freaks from Outer Space (with small, agile monsters), the game was retooled as ZombiU after the development team realized that the Wii U GamePad was suitable for slower-paced games. Ubisoft was approached by Nintendo to develop a mature game for its gaming console, Wii U. The port, handled by Straight Right, adds new melee weapons and removes the multiplayer feature. The game was released under the name Zombi for PlayStation 4, Windows, and Xbox One in 2015. Featuring a permadeath system, it uses the Wii U GamePad extensively to scan the environment and maintain the survivor's inventory. In the game, the player assumes control of a human survivor amid a 2012 zombie apocalypse. It was released for the Wii U as one of its launch games in November 2012. ZombiU is a first-person survival horror video game developed by Ubisoft Montpellier and published by Ubisoft.

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